Inhibition of Soybean and Potato Lipoxygenases by Bhilawanols from Bhilawan (Semecarpus anacardium) Nut Shell Liquid and Some Synthetic Salicylic Acid Analogues |
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Authors: | Kyatanahalli S Nagabhushana S Umamaheshwari Felismino E Tocoli Sandeep K Prabhu Ivan R Green Candadai S Ramadoss |
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Institution: | 1. Max-Planck Institute für Kohlenforschung, Kaiser-Wilhelm-Platz-1, D 45470 Mülheim an der Ruhr, Germany;2. Vittal Mallya Scientific Research Foundation, K.R. Road, Bangalore, India;3. Department of Chemistry, University of the Western Cape, Cape Town, Republic of South Africa;4. Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, USA |
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Abstract: | Bhilawanol diene (3) isolated from bhilawan nut shell liquid was found to be a potent inhibitor of both soybean and potato lipoxygenases with IC 50 values of 0.85 μM and 1.1 μM, respectively. However, the monoene (2) and saturated (1) bhilawanols exhibited relatively lower inhibitory activity. In addition, inhibition studies with synthetic analogues of salicylic acid (4 - 8) suggested that the unsaturated lipophilic side chain may be an absolute requirement for inhibitory activity. |
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Keywords: | Bhilawanols Semecarpus Anacardium Soybean Lipoxygenase Potato Lipoxygenase Inhibition Urushiol |
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