Carbonic Anhydrase Inhibitors: Schiff's Bases of Aromatic and Heterocyclic Sulfonamides and their Metal Complexes |
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| Authors: | Mahmood- Ul-Hassan Zahid H. Chohan Andrea Scozzafava Claudiu T. Supuran |
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| Affiliation: | 1. Department of Chemistry Islamia University Bahawalpur Pakistan;2. Department of Chemistry Bahauddin Zakariya University Multan Pakistan;3. Università degli Studi di Firenze Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica Rm. 188, Via della Lastruccia 3 I-50019 Sesto Fiorentino (Firenze) Italy |
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| Abstract: | Schiff's bases were obtained from aromatic/heterocyclic sulfonamides and amino-sulfonamide derivatives, such as sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide and 5-amino-1,3,4-thiadiazole-2-sulfonamide. Metal complexes of some of these Schiff's bases, incorporating Zn(II), Co(II), Ni(II) and Cu(II) ions, were also prepared and tested as inhibitors of the zinc enzyme carbonic anhydrase (CA), and more specifically the red blood cell isozymes I and II. The Schiff's bases behaved as medium potency CA I and CA II inhibitors, whereas their metal complexes showed a highly enhanced potency, with several low nanomolar CA II inhibitors detected. |
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| Keywords: | Carbonic anhydrase Isozymes I, II Aromatic/Heterocyclic sulfonamides Schiff base Metal complexes |
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