Spectral analysis and in vitro cytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid |
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| Authors: | M I Khan Musa Kaleem Baloch Muhammad Ashfaq |
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| Institution: | 1. Department of Chemistry, Gomal University, D.I. Khan, Pakistan;2. Department of Chemistry, Islamia University, Bahawalpur, Pakistan |
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| Abstract: | Six novel triorganotin(IV) 2-maleimidopropanoato complexes: R3SnOCOCH3(CH)(COCH)2, (R: Me(1), Et(2), n-Pr(3), n-Bu(4), Ph(5), Bz(6) have been synthesized. Their solid-state configuration has been determined by FT IR and 119mSn Mössbauer spectroscopy. The tin(IV) atom is five-coordinated in all the complexes with 2-maleimidopropanoic acid behaving as a monoanionic bidentate ligand coordinating the tin(IV) atom through a chelating or bridging carboxylate group. The solution-state configuration has been elucidated by means of 1H-, 13C- and 119Sn-NMR spectroscopy which assigned a tetrahedron. Elemental analysis and FAB MS data also supported a 1:1 metal to ligand stoichiometry. The title complexes have been screened in vitro for anti-tumour, anti-fungal, anti-leishmanial and urease inhibition activities and displayed promising results. |
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| Keywords: | Triorganotin(IV) 2-maleimidopropanoic acid urease inhibition anti-tumour anti-leishmanial anti-fungal |
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