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Synthesis of Aldehydo-sugar Derivatives of Pyrazoloquinoline as Inhibitors of Herpes Simplex Virus Type 1 Replication |
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| Authors: | Adnan A Bekhit Ola A El-Sayed Yunus M Siddiqui Mohammed N Al-Ahdal |
| Institution: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, 21521, Alexandria, Egypt;2. Molecular Virology and Infectious Diseases Laboratory, Biological and Medical Research Department (MBC), King Faisal Specialist Hospital and Research Centre, P.O. Box 11211, Riyadh, Saudi Arabia |
| Abstract: | Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined. |
| Keywords: | Pyrazoloquinoline nucleosides cytotoxicity anti-HSV-1 acute toxicity |