Antibacterial,antifungal, insecticidal,cytotoxicity and phytotoxicity studies on Indigofera gerardiana |
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Authors: | Muhammad Nisar Shafiq Ahmad Tariq Inamullah Khan Marwat Muhammad Raza Shah Ihsan Ali Khan |
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Affiliation: | 1. Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, NWFP, Pakistanakund_54@yahoo.co.uk;3. Department of Pharmacy, University of Peshawar, Peshawar, Pakistan 25120;4. HEJ Research Institute, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan |
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Abstract: | The antibacterial, antifungal, acute cytotoxicity, phytotoxicity and insecticidal profile of the crude extract and various fractions of Indigofera gerardiana have been studied. Six bacterial and fungal strains were used, of which Samonella typhi and Microsporum canis were the most susceptible strains with MICs 0.37 mg/mL and 0.09 mg/mL, respectively. The crude extract and the fractions showed low insecticidal activity against Sitophilus oryzae, Rhyzopertha dominica and Callosbruchus analis but no activity against Tribolium castaneum. The brine shrimp lethality assay showed absence of any measurable cytotoxicity of the crude extract and fractions, showing a good safety profile at a preliminary level. All the fractions except crude extract revealed profound and highly significant herbicidal activity against Lemna minor at the concentration of 1000 μg/mL. Indigofera gerardiana was shown by in-vitro assays to be a potential source for natural antifungal, antibacterial and herbicidal agents. |
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Keywords: | Indigofera gerardiana antibacterial antifungal insecticidal herbicidal |
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