Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives |
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| Authors: | M Shahar Yar M Afroz Bakht A A Siddiqui M M Abdullah Erik De Clercq |
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| Institution: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, 110062, Indiayarmsy@rediffmail.com;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, 110062, India;4. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium |
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| Abstract: | Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between 2-{4-3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} acetic acid and substituted acid hydrazides and were tested for their in vitro cytotoxicity and antiviral activity. None of the compounds showed any specific antiviral activity 50% antivirally effective concentration (EC50) ≥ 5-fold lower than minimum cytotoxic concentration]. The most cytotoxic of the series was 2-{4-3-(2,4-dihydroxyphenyl)-1-(2-hydroxybenzoyl-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid (3j), with a minimum cytotoxic concentration of 0.16 μg/mL in human embryonic lung (HEL) cells. |
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| Keywords: | Pyrazoline antiviral cytotoxic |
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