Synthesis of some 4-arylidenamino-4H-1,2,4-triazole-3-thiols and their antituberculosis activity |
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Authors: | Ahmet Özdemir Gulhan Turan-Zitouni Zafer Asim Kaplancikli Pierre Chevallet |
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Affiliation: | 1. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470, Eskisehir, Turkey;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Montpellier UniversityI, LAAP, CNRS-UMR 5810, 34000, Montpellier, France |
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Abstract: | The increasing clinical importance of drug-resistant mycobacterial pathogens has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new triazoles were synthesized and evaluated for antituberculosis activity. A series of 4-arylidenamino-4H-1,2,4-triazole-3-thiol derivatives (2a–n) were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles-3-thiol (1) with the respective aldehydes and were evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv (ATCC 27294), using the BACTEC 460 radiometric system and BACTEC 12B medium. Compound 2k showed an intereting activity at 6.25 μg/mL with a 87 percentage inhibition. |
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Keywords: | 4-Arylidenamino-4H-1,2,4-triazole-3-thiol mycobacterium tuberculosis antimycobacterials |
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