Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity |
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| Authors: | Zahid H. Chohan Mohammad S. Iqbal Hummara Sadia Iqbal Andrea Scozzafava Claudiu T. Supuran |
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| Affiliation: | 1. Department of Chemistry, Islamia University, Bahawalpur, Pakistan;2. Army Welfare Pharmaceuticals, Head Baloki Road, Bhai Pheru, Lahore, Pakistan;3. Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, University of Florence, Polo Scientifico, Via della Lastruccia 3, Rm 188, 50019 Sesto Fiorentino (Firenze), Italy |
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| Abstract: | Mononuclear and binuclear transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] acetylsalicylates of the type [M(L) 2], [M(L) 2 Cl 2] and [(M) 2 (L) 4] have been prepared and characterized on the basis of their physical, spectral and analytical data. The complexes have been investigated in an in vivo animal model for anti-inflammatory activity and show a better effect and a more potent action than acetylsalicylic acid. |
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| Keywords: | Acetyl Salicylic Acid Transition Metal Ion Complex Anti-inflammatory Agent |
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