Anti-tubercular Activity of Ruthenium (II) Complexes with Polypyridines |
| |
Authors: | Taibi Ben Hadda Mehmet Akkurt Mohamed Filali Baba Maria Daoudi Brahim Bennani Abdelali Kerbal |
| |
Institution: | 1. Laboratoire Chimie des Matériaux, Faculté des Sciences, 60000, Oujda, Moroccotbenhadda@yahoo.fr";4. Department of Physics, F.A.S., Erciyes University, 38039, Kayseri, Turkey;5. Laboratoire Chimie Organique, Faculté des Sciences Dhar El Mehraz, 30000, Fès, Morocco |
| |
Abstract: | A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2′-bipyridines; 2,2′-6′,2′-terpyridines, di-alkyloxy-2,2′-6,2-bipyridine-3,3′-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1–10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds. |
| |
Keywords: | Ruthenium (II) complexes polypyridines anti-tubercular activity |
|
|