Synthesis,antimicrobial and antiviral activity of substituted benzimidazoles |
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Authors: | Deepika Sharma Pradeep Kumar Vikramjeet Judge Rakesh Narang Erik De Clercq |
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Affiliation: | 1. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India;2. Laboratory of Virology &3. Chemotherapy, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven. Belgium |
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Abstract: | In the present study we have synthesized (4-nitrophenyl)-[2-(substituted phenyl)-benzoimidazol-1-yl]-methanones, (2-bromophenyl)-[2-(substituted phenyl)-benzoimidazol-1-yl]-methanone analogues (1–14) and evaluated them for their antimicrobial and antiviral potential. The results of antimicrobial screening indicated that none of the synthesized compounds were effective against the tested bacterial strains. Compounds 3, 11, 13 and compounds 5, 11, 12 were found to be active against Aspergillus niger and Candida albicans respectively, and may be further developed as antifungal agents. Furthermore, evaluation against a panel of different viruses pointed out the selective activity of compounds 5 and 6 against vaccinia virus and Coxsackie virus B4. |
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Keywords: | Substituted benzimidazoles antifungal activity antiviral activity |
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