|
|||||
|
|
Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa |
|
| Authors: | IJAZ AHMAD SHILIN CHEN YONG PENG SIBAO CHEN LIJIA XU |
| Affiliation: | 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China;2. State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 518057, China |
| Abstract: | Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1–7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC50 value of 39.7 ± 0.02μM, along with DPPH radical scavenging activity with IC50 value 0.638 mM. |
| Keywords: | Buddleja crispa Buddlejaceae iridoids lipoxygenase inhibition antioxidant Buddleia |