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Joint Confidence Sets in Multiple Dilution Assays
Authors:D. R. Jensen
Abstract:Let {Q1, …, Qk} be the potencies of k substances relative to a standard in a multiple dilution assay. Joint confidence bounds for these are given with confidence coefficient at least 1-α. These bounds are easily interpreted; they appeal to available tables; they improve Scheffe's bounds; they are based on applicable probability inequalities together with extensions of Fieller's theorem; and they are genuinely nonparametric. The procedures are illustrated using data from parallel-line and slope-ratio assays.
Keywords:Relative potencies  Conservative confidence bounds  Fieller's theorem  Ellipsoidal distributions  Nonparametrics
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