|
|||||
|
|
Direct chromatographic separation of 2-arylpropionic acid enantiomers using tris(3,5-dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases |
|
| Authors: | Yoshio Okamoto Ryo Aburatani Yuriko Kaida Koichi Hatada Nobuo Inotsume Masahiro Nakano |
| Abstract: | Direct optical resolution of antiinflammatory drugs such as ibuprofen, ketoprofen, flurbiprofen, and tiaprofenic acid were attempted by high-performance liquid chromatography using tris(3,5-dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases. Although ibuprofen was not sufficiently resolved, the other three 2-arylpropionic acids were completely resolved by amylose tris(3,5-dimethylphenylcarbamate). Ibuprofen was resolved as anilide derivative. |
| Keywords: | optical resolution HPLC chromatography antiinflammatory drug ibuprofen ketoprofen flurbiprofen tiaprofenic acid |