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Optical resolution of β-lactams by chiral HPLC on tris(phenylcarbamate)s of cellulose and amylose |
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| Authors: | Yoshio Okamoto Toshiaki Senoh Harumi Nakane Koichi Hatada |
| Abstract: | Separation and optical resolution of 6 diastereomers and 25 racemates of β-lactams were examined by HPLC on chiral stationary phases composed of six cellulose and one amylose tris(phenylcarbamate) derivatives. Most β-lactams were optically resolved at least by one of the derivatives. The absolute configuration of β-lactams was estimated by CD spectroscopy. |
| Keywords: | 4-acetoxy-2-azetidinone antibiotics carbapenem chiral stationary phases cellulose tris(phenylcarbamate) amylose tris(3,5-dimethylphenylcarbamate) CD spectra absolute configuration |