Down-regulation of phospholipase D during differentiation of mouse F9 teratocarcinoma cells. |
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| Authors: | D S Min K S Shin E G Kim S R Kim S H Yoon M S Kim Y H Jo |
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| Institution: | Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. dsmin@cmc.cuk.ac.kr |
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| Abstract: | Phospholipase D has been recognized as playing an important role in signal transduction in many types of cells. We investigated the expression of phospholipase D during the differentiation of F9 embryonal teratocarcinoma cells. The ADP ribosylation factor-dependent phospholipase D activity, as measured by an in vitro assay, and H2O2-induced phospholipase D activity and phospholipase D protein content in whole cells were decreased during the differentiation of F9 cells induced by a combination of dibutyryl cyclic AMP and all-trans retinoic acid. In contrast, these changes were not observed when cells were induced by retinoic acid. These results suggest that down-regulation of phospholipase D protein is associated with differentiation of F9 cells to a parietal endoderm lineage. |
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