Preserved MHC-II antigen processing and presentation function in chronic HCV infection |
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| Authors: | Canaday D H Burant C J Jones L Aung H Woc-Colburn L Anthony D D |
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| Institution: | aGRECC, Louis Stokes Cleveland VA Hospital, United States;bDivision of Infectious Disease, Case Western Reserve University School of Medicine, United States;cSchool of Nursing, Case Western Reserve University, United States;dSection of Infectious Disease, Baylor College of Medicine, United States;eDivision of Rheumatology, Case Western Reserve University School of Medicine, United States |
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| Abstract: | Individuals with chronic HCV infection have impaired response to vaccine, though the etiology remains to be elucidated. Dendritic cells (DC) and monocytes (MN) provide antigen uptake, processing, presentation, and costimulatory functions necessary to achieve optimal immune responses. The integrity of antigen processing and presentation function within these antigen presenting cells (APC) in the setting of HCV infection has been unclear. We used a novel T cell hybridoma system that specifically measures MHC-II antigen processing and presentation function of human APC. Results demonstrate MHC-II antigen processing and presentation function is preserved in both myeloid DC (mDC) and MN in the peripheral blood of chronically HCV-infected individuals, and indicates that an alteration in this function does not likely underlie the defective HCV-infected host response to vaccination. |
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| Keywords: | Hepatitis C Immunology Dendritic cells Monocytes Antigen presentation MHC-II |
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