Extracellular acidosis promotes neutrophil transdifferentiation to MHC class II-expressing cells |
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Authors: | Pliyev Boris K Sumarokov Alexander B Buriachkovskaia Lyudmila I Menshikov Mikhail |
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Affiliation: | aDepartment of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Moscow State University, Lomonosovsky Pr., 31-5, Moscow 119192, Russia;bDepartment of Biochemistry, Institute of Experimental Cardiology, Cardiology Research Centre, 3rd Cherepkovskaya Str., 15a, Moscow 121552, Russia |
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Abstract: | Inflammation in peripheral tissues is usually associated with local acidosis. In the present study, we demonstrate that extracellular acidification enhances GM-CSF- and IFN-γ-induced expression of HLA-DR, CD80 and CD86 in human neutrophils (neutrophil transdifferentiation), and potentiates antigen-capturing capacities (both endocytosis and phagocytosis) of the transdifferentiated cells. Furthermore, in acidic conditions the transdifferentiated neutrophils have stronger antigen-presenting capacity, inducing more intense proliferation of autologous T lymphocytes in the presence of staphylococcal enterotoxin A. Thus, extracellular acidosis can represent a factor that promotes neutrophil transdifferentiation and potentiates the functional abilities of the transdifferentiated cells in inflammatory foci in vivo. |
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Keywords: | Neutrophil transdifferentiation Extracellular acidosis MHC class II |
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