Cholecystokinin octapeptide significantly suppresses collagen-induced arthritis in mice by inhibiting Th17 polarization primed by dendritic cells |
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| Authors: | Li Qiaoxia Han Dongyan Cong Bin Shan Baoen Zhang Jingge Chen Haiying Ma Chunling Liyanage Surabhi S |
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| Institution: | aInstitute of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei Province, PR China;bResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, PR China;cDepartment of Pathology, The Tenth Hospital of Shanghai, Shanghai, PR China;dSchool of Public Health and Community Medicine, University of New South Wales, Sydney, Australia |
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| Abstract: | Cholecystokinin octapeptide (CCK-8) is a neuropeptide, and is shown to be a potent immunomodulator with predominant anti-inflammatory effects. Although the regulatory effect of CCK-8 on macrophages and B cells has been defined, the effect of CCK-8 on dendritic cells (DCs) and T cells is not well understood. In this study, we showed that CCK-8 reduced the expression of CD80, CD86, and MHCII on DCs. Moreover, CCK-8 promoted Th1 and inhibited Th17 polarization by increasing the production of IL-12 and decreasing the production of IL-6 and IL-23 on DCs in vitro and in vivo. In addition, intraperitoneal administration of CCK-8 to mice with collagen-induced arthritis (CIA) was found to effectively reduce the incidence of arthritis, delay its onset and prevent the occurrence of joint damage. Collectively, these results suggest that CCK-8 significantly suppresses the incidence and severity of CIA in mice, through the inhibition of DC mediated Th17 polarization. |
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| Keywords: | Cholecystokinin octapeptide Dendritic cell CD4+ T cell Th17 cell Collagen-induced arthritis |
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