Cancer of the gastrointestinal tract results in a restricted T-cell repertoire dependent upon tumor differentiation |
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Authors: | Luo Wei Liao Wang-Jun Huang Yong-Ta Shi Min Zhang Yuan Wen Qian Zhou Ming-Qian Ma Li |
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Institution: | aInstitute of Molecular Immunology, School of Biotechnology, Southern Medical University, Guangzhou 510515, China;bDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China |
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Abstract: | We investigated the influence of tumor tissue differentiation on the diversity of TCR repertoire. CDR3 spectratypes of CD4+ and CD8+ T cell subsets were analyzed from 27 patients with gastrointestinal tract tumors exhibiting varying degrees of differentiation. A CDR3 spectratype complexity scoring system was used to quantify the diversity of TCR repertoire. Each patient was matched with an age-matched healthy group to control for age variability. Results show that the complexity scores (TCR repertoire diversity) have a significant correlation with the degree of tumor differentiation, which provides useful information for understanding immune response in cancer patients. |
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Keywords: | T cell receptor (TCR) Tumor differentiation Complementarity-Determining Region 3 (CDR3) T cell repertoire |
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