Advantage of higher-avidity CTL specific for Tax against human T-lymphotropic virus-1 infected cells and tumors |
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| Authors: | Kitazono Takako Okazaki Takahiro Araya Natsumi Yamano Yoshihisa Yamada Yasuaki Nakamura Tatsufumi Tanaka Yuetsu Inoue Makoto Ozaki Shoichi |
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| Institution: | aDivision of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan;bDepartment of Molecular Medical Science, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan;cDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;dThe Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;eDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan |
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| Abstract: | Strong CTL response can be observed and associated with the control of proviral load in human T-lymphotropic virus type 1 (HTLV-1) infection. However, there are few details with regard to how HTLV-1 specific CTLs work against HTLV-1 infected cells and adult T-cell leukemia cells (ATLs). In this study, using Tax-specific CTL lines with high- and low-functional avidity developed from HLA-A2-transgenic mice, we showed that higher avidity CTLs specific for Tax expressing larger numbers of TCRs and better binding strength to the antigen-HLA-A2 complex are much more efficient at eliminating HTLV-1 infected cells and, in particular, ATL tumor cells with the ability of recognizing a latent level of Tax product detected only with a real-time PCR. These findings suggest that such higher avidity CTLs specific for Tax in HTLV-1 could be responsible for preventing the development of HTLV-1 infection by detecting trace amount of antigens. |
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| Keywords: | ATL Avidity Cytotoxic T-cell (CTL) HTLV-1 HLA-A2 transgenic mice |
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