Effects of age, gender and time on receptor expression and anti-Aspergillus functions of human phagocytes |
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| Authors: | Aldebert Delphine Hypolite Magali Bal Gaelle Dumestre-Pérard Chantal Bertini Rose-Laurence Rolland Carole Boutonnat Jean Grillot Renée Pelloux Hervé Brion Jean Paul |
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| Affiliation: | aLaboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier Grenoble, CNRS UMR 5163, Grenoble, France;bParasitologie-Mycologie Département des Agents Infectieux, Pôle Biologie, Centre Hospitalier Universitaire, Grenoble, France;cClinical Research Center, INSERM CIC03, France;dLaboratoire d’Immunologie, Pôle Biologie, Centre Hospitalier Universitaire, Grenoble, France;eDépartement d’Anatomie et Cytologie Pathologiques, Pôle Biologie, Université Joseph Fourier, CNRS UMR 5525, France;fRéanimation Médicale et Maladie Infectieuse, Pôle Médecine Aigüe et Communautaire, Centre Hospitalier Universitaire, Grenoble, France |
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| Abstract: | Phagocytes play a central role in immune defense. Their dysfunction predisposes to infections. This study determined the expression level of nine receptors involved in Aspergillus immune response as well as the values of phagocytosis and production of radical oxygen species after Aspergillus stimulation, in a healthy adult population.The expression values of the CD11b, CD11c, CD14, CD18, CD35, CD181, CD182, CD282 and CD284 receptors on peripheral human monocytes and granulocytes was established. A heterogenous expression of the CD282 on granulocytes was observed as CD181, CD182 and CD284 on monocytes. Similarly, we observed considerable variation in the expression of these receptors over time. Only CD282 on granulocytes varied with sex. No variation with age was observed. Adherence of Aspergillus conidia to phagocytes was dependent of individual, sex, age and time. A better characterization of these innate immunity parameters is necessary to develop in the future an immunologic surveillance strategy for transplant recipients. |
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| Keywords: | Monocyte Granulocyte Human leukocyte differentiation antigen Immune adherence reaction Respiratory burst Blood donor Monitoring Transplant recipient |
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