The properties of bioengineered chondrocyte sheets for cartilage regeneration |
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Authors: | Genya Mitani Masato Sato Jeong IK Lee Nagatoshi Kaneshiro Miya Ishihara Naoshi Ota Mami Kokubo Hideaki Sakai Tetsutaro Kikuchi Joji Mochida |
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Affiliation: | (1) Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan;(2) Department of Medical Engineering, National Defense Medical Collage, Saitama, Japan;(3) CellSeed Inc., Tokyo, Japan |
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Abstract: | Background Although the clinical results of autologous chondrocyte implantation for articular cartilage defects have recently improved as a result of advanced techniques based on tissue engineering procedures, problems with cell handling and scaffold imperfections remain to be solved. A new cell-sheet technique has been developed, and is potentially able to overcome these obstacles. Chondrocyte sheets applicable to cartilage regeneration can be prepared with this cell-sheet technique using temperature-responsive culture dishes. However, for clinical application, it is necessary to evaluate the characteristics of the cells in these sheets and to identify their similarities to naive cartilage. |
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