Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5 |
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| Authors: | Nessan Bermingham Renate Hillermann Fraser Gilmour Joanne E. Martin Elizabeth M. C. Fisher |
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| Affiliation: | (1) Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, Norfolk Place, W2 1PG London, UK;(2) Department of Histopathology, The London Hospital Medical College, E1 1BB Whitechapel, London, UK |
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| Abstract: | Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. We have mapped the gene encoding GDNF by two independent methods: using a cell hybrid panel and by fluorescent in situ hybridisation. We find GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3 |
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