Effect of 6059-S,a novel oxacephem,on cross-linking reaction of peptidoglycan biosynthesis in Escherichia coli,Pseudomonas aeruginosa and Serratia marcescens |
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| Authors: | Naoki Takata Michio Ogawa Goro Kosaki Hidekazu Suginaka |
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| Institution: | (1) Second Department of Surgery, Osaka University Medical School, 553 Fukushima-ku, Osaka, Japan;(2) Department of Microbiology and Oral Bacteriology, Osaka University Dental School, 530 Kita-ku, Osaka, Japan |
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| Abstract: | The effect of 6059-S, a novel 1-oxacephem, on peptidoglycan synthesis was investigated using ether-treated cells of Escherichia coli K 12, Pseudomonas aeruginosa KM 338 and Serratia marcescens IFO 12648. The cross-linking reaction of peptidoglycan synthesis in these organisms was inhibited by markedly low concentration of 6059-S.Non-standard abbreviations PBP
penicillin binding protein
- MIC
minimum inhibitory concentration
- ETB
ether treated bacterial cells
- SDS
sodium dodecylsulfate |
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| Keywords: | Inhibition of peptidoglycan synthesis 6059-S Oxacephem Escherichia coli Pseudomonas aeruginosa Serratia marcescens |
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