The highly conserved tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex and is required for the G2/M phase transition in the yeast Saccharomyces cerevisiae |
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| Authors: | Rice Terri S Ding Min Pederson David S Heintz Nicholas H |
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| Affiliation: | Department of Pathology, Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA. |
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| Abstract: | Here we show that the Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p interacts with the origin recognition complex in vivo and in vitro and that overexpression of hemagglutinin-Thg1p selectively impedes growth of orc2-1(Ts) cells at the permissive temperature. Studies with conditional mutants indicate that Thg1p couples nuclear division and migration to cell budding and cytokinesis in yeast. |
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