Relative efficiencies of a series of square-planar plantinum(II) compounds on Salmonella mutagenesis. |
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Authors: | P Lecointe J P Macquet J L Butour C Paoletti |
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Institution: | Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS 205, route de Narbonne, 31078 Toulouse Cédex, France |
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Abstract: | Twelve Pt(II) compounds have been tested for mutagenicity on Salmonella typhimurium (strain TA 100). Very high mutagenic activities were found for the cis derivatives. A correlation is suggested between these results and a formerly described model of chemical reactivity towards DNA, according to which cis derivatives from intra-strand chelates with guanine. A smaller activity was found with monodentate complexes with DNA. |
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