Proof of proteolytic activity of hemorrhagic toxins, HR-2a and HR-2b, from Trimeresurus flavoviridis venom |
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| Authors: | T Nikai M Niikawa Y Komori S Sekoguchi H Sugihara |
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| Institution: | Department of Microbiology, Faculty of Pharmacy, Meijo University, Tenpanku-Ku, Nagoya, Japan |
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| Abstract: | Two hemorrhagic toxins, HR-2a and HR-2b were originally isolated from Trimeresurus flavoviridis (Habu) venom by Takahashi and Ohsaka (1970). It was reported by the original investigators that no proteolytic activity was detected when casein was used as the substrate. HR-2a and HR-2b were isolated in this laboratory and their proteolytic activities were tested using a variety of different substrates and assay methods. HR-2a and HR-2b were found to contain, respectively, 200 and 219 amino acid residues. Toxicological and biochemical properties of HR-2a and HR-2b were further investigated and are reported in this paper. |
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