Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles |
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| Authors: | Minhas Gurpreet Singh Pilch Daniel S Kerrigan John E LaVoie Edmond J Rice Joseph E |
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| Affiliation: | Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA. |
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| Abstract: | The synthesis of 24-membered macrocycles containing four, six, and seven oxazole moieties is described. Selected compounds were evaluated for their ability to specifically bind and stabilize G-quadruplex DNA and for cytotoxic activity. An unexpected oxidative cleavage reaction afforded a macrocyclic imide that was also evaluated for G-quadruplex stabilizing and cytotoxic activity. |
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