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Only through the brain nuclei, arginine vasopressin regulates antinociception in the rat |
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| Authors: | Yang Jun Song Cao-You Liu Wen-Yan Lin Bao-Cheng |
| Institution: | aInstitute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianghai District, Jiangmen, Guangdong 529000, China bInstitute for Neurisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada C1A5T1 cDepartment of Neurobiology, Second Military Medical University, Shanghai 200433, China dDepartment of Physiology, Jining Medical College, Jining, Shandong 272113, China |
| Abstract: | The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100 ng AVP dose-dependently increased the pain threshold; in contrast, intraventricular injection of 10 μl anti-AVP serum decreased the pain threshold; both intrathecal injection of 200 ng AVP or 10 μl anti-AVP serum and intravenous injection of 5 μg AVP or 200 μl anti-AVP serum did not influence the pain threshold. Pain stimulation reduced AVP concentration in hypothalamic paraventricular nucleus (PVN), and elevated AVP concentration in hypothalamic supraoptical nucleus (SON) and periaqueductal gray (PAG), but no change in AVP concentration was detected in pituitary, spinal cord and serum. The results indicated that AVP regulation of antinociception was limited to the brain nuclei. |
| Keywords: | Arginine vasopressin Anti-arginine vasopressin serum Antinociception Hypothalamic paraventricular nucleus Periaqueductal gray Rat |
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