Évaluation de la TEP au 18F-FDG dans la tuberculose extrapulmonaire : premiers résultats d’une étude pilote observationnelle |
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Authors: | N. Mortazavi-Jehanno K. JidarK. Ben Ali C. RiouxS. Burg T. PoissonV. Joly D. Le GuludecP. Yeni L. Sarda-Mantel |
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Affiliation: | a Service de médecine nucléaire, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France b Service de maladies infectieuses, hôpital Bichat, 75877 Paris, France |
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Abstract: | AimExtrapulmonary tuberculosis treatment is difficult to assess and there is a need for new tools. The aim of this observational pilot study is to evaluate the potential role of 18F-FDG PET/CT in the initial staging and treatment evaluation of extrapulmonary tuberculosis.MethodsTwenty-eight patients were included between January 2009 and 2010. Twenty-three had a 18F-FDG PET/CT before treatment and/or during and/or after treatment. All patients will be followed for 18 months after the end of treatment. A control group of five patients with previous history of tuberculosis was also included and PET/CT was performed.ResultsThree cases of differential diagnosis were excluded of the study. The initial PET for staging showed additional lesions in 8/10 patients compared to conventional imaging. At the end of treatment, 6/11 patients had a negative PET, and 5/11 patients had a positive PET. PET had a significant clinical impact for 3/10 patients at initial staging (guiding biopsy or increase of planned treatment duration), and for 3/16 during follow up (extend or early interruption of the treatment). All PET scans in the control group were negative.Conclusion18F-FDG PET has an excellent sensitivity for the detection of extrapulmonary tuberculosis lesion and excellent negative predictive values. The impact of initial PET staging seems significant. The interest of 18F-FDG PET for the evaluation of response to treatment remains to be assessed and will be correlated with patients’ follow up in a second phase of this study. |
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Keywords: | Tuberculose TEP/TDM 18F-FDG |
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