Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis in Saccharomyces. |
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| Authors: | John E Golin and Michael S Esposito |
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| Institution: | (1) Erman Biology Center, Department of Biology, University of Chicago, Chicago, Illinois, USA;(2) Committee on Genetics, University of Chicago, Chicago, Illinois, USA |
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| Abstract: | Summary A procedure for detection of mutants exhibiting either enhanced or reduced spontaneous mutation during mitosis and/or meiosis has been developed to probe the joint genic control of spontaneous mutation and recombination in yeast. A semidominant mutator,rem1-1, recovered by this technique, exhibits enhanced spontaneous mutation, intragenic recombination, and intergenic recombination during mitosis. Diploids homozygous forrem1-1 exhibit normal levels of meiotic intragenic and intergenic recombination and diminished ascospore viability. |
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