Transplantation of bone marrow stromal cells enhances nerve regeneration of the corticospinal tract and improves recovery of neurological functions in a collagenase-induced rat model of intracerebral hemorrhage |
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Authors: | Hongsheng Liang Yibo Yin Tie Lin Dong Guan Bowen Ma Changyu Li Yuehua Wang Xiangtong Zhang |
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Affiliation: | 1. Oral Biology Research Institute, Chosun University School of Dentistry, Gwangju, Korea 2. Department of Biotechnology, Chosun University, Gwangju, Korea 3. Regional Innovation Center for Dental Science and Engineering, Chosun University, Gwangju, Korea 4. Department of Oral Physiology, College of Dentistry, Institute of Wonkwang Biomaterial and Implant, Wonkwang University, Iksan, Korea
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Abstract: | MicroRNA (miRNA) is a form of small noncoding RNA that regulates the expression of genes either by inhibiting mRNA translation or by inducing its degradation. Small microRNA play important roles in regulating a large number of cellular processes, including development, proliferation and apoptosis. This study examined the biological functions of miR-205 as a tumor suppressor in KB oral cancer cells. The results showed that miR-205 expression was significantly lower in KB oral cancer cells than in human normal oral keratinocytes. Furthermore, the miR-205 over-expressed in KB oral cancer cells increased the cell cytotoxicity and induced apoptosis through the activation of caspase-3/-7. The transfection of miR-205 into KB oral cancer cells strongly induced IL-24, a well known cytokine that acts as a tumor suppressor in a range of tumor tissues. In addition, miR-205 targeted the IL-24 promoter directly to induce gene expression. Overall, miR-205 has significant therapeutic potential to turn on silenced tumor suppressor genes by targeting them with miRNA. |
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Keywords: | apoptosis human oral cancer interleukin-24 microRNA-205 |
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