Lipid metabolism in Cryptococcus neoformans |
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Authors: | Shea John M Henry Jennifer L Del Poeta Maurizio |
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Affiliation: | Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA. |
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Abstract: | In recent years, lipids have been shown to act as signalling molecules not only in mammalian cells but also in many other eukaryotes. Whereas in mammalian cells lipids regulate cellular functions that play crucial roles in the regulation of pathobiological processes, such as cancer, cardiovascular and neurodegenerative disorders, and inflammation, in the fungus Cryptococcus neoformans lipids play key roles in the regulation of pathogenic traits required for the development of cryptococcosis, an infectious disease particularly frequent in immunocompromised individuals. In this minireview we discuss recent advances in the understanding of lipid metabolism in this important human pathogen, highlighting the potential of fungal lipid enzymatic pathways as promising new drug targets. |
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Keywords: | lipid metabolism phospholipase Cryptococcus neoformans pathogenicity eicosanoid sphingolipid |
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