Calcium and phosphate metabolism in uranyl nitrate-induced acute renal failure |
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Authors: | V Stefanovi? M A Ivi? S Strahinji? |
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Affiliation: | Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Yugoslavia. |
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Abstract: | Plasma calcium regulation in uranyl nitrate-treated dogs was studied. A discrete hypercalcemia was observed without significant changes in the level of plasma ionized calcium. Serum phosphate increased markedly following uranyl nitrate treatment. A sharp rise of iPTH was demonstrated. Uranyl nitrate-induced acute renal failure in dogs was found to be a useful model for studying the mechanisms regulating calcium and phosphate metabolism. |
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