Sensitivity of cultured rat hepatocytes to aflatoxin B1 and benzo(a)pyrene |
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| Authors: | Warren I Schaeffer A H L Chuang Nicholas Heintz Edward Bresnick |
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| Institution: | (1) Department of Medical Microbiology, University of Vermont College of Medicine, Given Medical Building, 05405 Burlington, Vermont;(2) Department of Biochemistry, University of Vermont College of Medicine, Given Medical Building, 05405 Burlington, Vermont |
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| Abstract: | Summary We have tested the sensitivity of a cloned rat hepatocyte line, RL-PR-C, to aflatoxin B1 and benzo(a)pyrene as a function of population-doubling level. The cells were much more sensitive to the cytotoxic action
of these agents subsequent to 230 population doublings. This sensitivity corresponded to the enhanced inducibility of arylhydrocarbon
hydroxylase activity by 3-methylcholanthrene.
Supported by Grants CA 21258 and CA 12056 from the National Cancer Institute. |
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| Keywords: | epithelial hepatocytes aflatoxin B1 aryl hydrocarbon hydroxylase benzo(a)pyrene |
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