Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation |
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| Authors: | Stéphane Genevay Axel Finckh Françoise Mezin Enrico Tessitore Pierre-André Guerne |
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| Affiliation: | 1. Division of Rheumatology, University Hospitals of Geneva, Avenue Beau-Séjour 26, 1211, Geneva 14, Switzerland
2. Division of Neurosurgery, University Hospitals of Geneva, rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland
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| Abstract: | Introduction Spontaneous resorption of disc herniation (DH) after sciatica is well documented. The matrix metalloproteinases (MMP)-1 and MMP-3 are enzymes potentially involved in this process. Glucocorticoid injections are commonly used for treatment, and other anti-inflammatory molecules like tumor necrosis factor (TNF) inhibitors are under clinical investigation. However, little is known about the effect of these molecules on DH resorption. |
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