Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling |
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| Authors: | Miguel Manzano Gaetano Lamberti Ivan Galdi María Vallet-Regí |
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| Affiliation: | (1) Department of Inorganic and Bioinorganic Chemistry of the Faculty of Pharmacy, Universidad Complutense de Madrid, Madrid, 28040, Spain;(2) Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Barcelona, Spain;(3) Department of Industrial Engineering, University of Salerno, Via Ponte don Melillo, 84084 Fisciano, Salerno, Italy; |
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| Abstract: | The release of a potent bone-resorption inhibitor such as zoledronate from a versatile drug delivery system such as SBA 15 has been modeled. The initial and boundary conditions have been defined, together with the system parameters, including the determination of equilibrium and transport parameters. Additionally, the experimental model of the same system has been observed to validate the prediction here developed. This approach represents a powerful tool for the designing of mesoporous implantable drug delivery systems because their release kinetics can be predicted in advance, and this leads to a considerable time and resources saving. |
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