A population-based age-period-cohort study of colorectal cancer incidence comparing Asia against the West |
| |
| Affiliation: | 1. School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong;2. Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong;1. Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong;2. School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong;1. Department of Social and Preventive Medicine, École de Santé Publique de l’Université de Montréal (ESPUM), 7101 Park Ave, Montreal, Quebec, H3N 1X9, Canada;2. Centre de recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), 850 St-Denis, Montreal, Quebec, H2X A09, Canada;1. Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France;2. Scottish Cancer Registry, Information Services Division, National Health Service National Services Scotland, South Gyle, Edinburgh, Scotland;3. Analytics and Informatics, Cancer Care Ontario, Toronto, ON, Canada;4. Cancer Institute New South Wales, Alexandria, NSW, Australia;5. National Cancer Registry Ireland, Cork, Ireland;6. Department of Epidemiology and Cancer Registry, Cancercare Manitoba, Winnipeg, MB, Canada;7. Danish Cancer Society, Copenhagen, Denmark;8. Cancer Society of New Zealand, Wellington, New Zealand;9. Prince Edward Island Cancer Registry, Charlottetown, PE, Canada;10. BC Cancer, Vancouver, BC, Canada;11. Nova Scotia Health Authority Cancer Care Program, Halifax, NS, Canada;12. Northern Ireland Cancer Registry, Queen''s University Belfast, Belfast, Northern Ireland;13. Western Australia Cancer and Palliative Care Network Policy Unit Health Networks Branch, Department of Health, Perth, WA, Australia;14. Victorian Cancer Registry, Cancer Council Victoria, Melbourne, VIC, Australia;15. Institute of Population-Based Cancer Research, Cancer Registry of Norway, Oslo, Norway;p. NB Cancer Network, Department of Health, Province of New Brunswick, Fredericton, NB, Canada;q. Department of Oncology and K G Jebsen Colorectal Cancer Research Center, Oslo University Hospital, Oslo, Norway;1. Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan 430071, China;2. Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China;1. Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK;2. New Cross Hospital, Wolverhampton, UK;3. Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University, London, UK |
| |
| Abstract: | BackgroundColorectal cancer (CRC) is the third most common cancer worldwide but incidence varied widely. Despite the role of genetics, CRC is also sensitive to macro-environmental factors. Few studies have ever compared across different countries/regions to suggest possible macro-environmental risk factors of CRC. We estimated the effects of age, period and cohort on the changes of incidence of colorectal cancer across different countries/regions.MethodsPoisson regression age-period-cohort (APC) models were conducted to estimate the age, period and cohorts effects on CRC incidence across the West (i.e., the UK, the US and Australia) and Asia (i.e. Japan, Hong Kong, Shanghai, Singapore and India). We maximized the length of the study period according to each country’s data availability.ResultsWestern populations show upward inflections for their 1950s–1960s cohorts, while Asian populations (except India) show downward inflections for their 1950s cohorts. Japanese population also shows upward inflections for its 1960s cohorts, similar to the Western populations. There are apparent upward inflections towards the more recent cohorts for Hong Kong, Shanghai and Singapore; nevertheless, the confidence intervals are wider towards the more recent cohorts.ConclusionOur findings imply an increasing risk of CRC in both Western and Asian populations as their younger cohorts reach older ages. These findings are consistent with the life course argument that macro-environmental changes associated with socio-economic development have specific effects that extend over the life course. Actions that pertain to altering lifestyle-related exposures over the life course are of great importance in combating young CRC risks in the future. |
| |
| Keywords: | Colorectal cancer Age-period-cohort Population-based Comparative study Incidence International Western Asian |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
