Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium |
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| Affiliation: | 1. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;3. Department of Pediatrics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;4. Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;1. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain;2. Universitat Pompeu Fabra (UPF), Barcelona, Spain;3. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;4. McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada;5. National Institute for Occupational Safety and Health (NIOSH), OH, USA;6. Oregon State University (OSU), Corvallis, OR, USA;7. University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada;8. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia;9. Université de Lyon, Université Lyon1 Claude Bernard, IFSTTAR, Unité Mixte de Recherche Épidémiologique et de Surveillance Transports Travail Environnement, Lyon, France;10. Massey University, Wellington, New Zealand;11. INRS-Institut Armand-Frappier, Université du Québec, Laval, Canada;12. Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel;13. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;14. German Cancer Research Center (DKFZ), Heidelberg, Germany;15. International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France;p. Institute of Occupational Medicine (IOM), Edinburgh, UK;q. Centre for Occupational and Environmental Health, Centre for Epidemiology, The University of Manchester, UK |
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| Abstract: | BackgroundParental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.AimTo examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0–14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.Material/methodsWe analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1–14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1–14 years), and recruitment time period.ResultsAdjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12–22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.ConclusionsAn increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children. |
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| Keywords: | Infant acute myeloid leukemia Childhood cancer Epidemiology Maternal age Paternal age Risk factors |
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