Risk of mycobacterial disease among cancer patients: A population-based cohort study in a TB endemic area |
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| Affiliation: | 1. Department of Medical Research, Taichung Veterans General Hospital, Taichung, 407, Taiwan;2. Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan;3. Ph. D Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan;4. Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan;5. National Taipei University of Nursing and Health Science, Taipei, 112, Taiwan;6. Center of Rheumatology and Immunology, China Medical University Hospital, Taichung, 404, Taiwan;7. College of Medicine, China Medical University, Taichung, 404, Taiwan;1. Department of Respiratory Medicine, Kobe City Hospital Organization Kobe City Medical Center West Hospital, 2-4 Ichibancho, Nagata-ku, Kobe, Hyogo 653-0013, Japan;2. Department of Respiratory Medicine, Ohara Memorial Kurashiki Healthcare Foundation, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama 710-8602, Japan;3. Department of Respiratory Medicine, Sakai City Medical Center, 1-1-1 Ebarajicho, Nishi-ku, Sakai, Osaka 593-8304, Japan;4. Department of Respiratory Medicine, National Hospital Organization Minami Kyoto Hospital, 11 Ashihara, Joyo, Kyoto 610-0113, Japan;1. Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, United States;2. Department of Urology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, United States;1. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada;2. Department of Urology, European Institute of Oncology, Milan, Italy;3. Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy;4. Martini-Klinik, Prostate Cancer Centre, University Hospital Hamburg-Eppendorf, Hamburg, Germany;5. Urology Unit, ASST Spedali Civili of Brescia. Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, Italy;6. Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy;7. Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada;8. Department of Urology, IRCCS Fondazione Ca’ Granda-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy;9. Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany;10. Department of Urology, Medical University of Vienna, Vienna, Austria;11. Dipartimento di Oncologia ed Emato-Oncologia, Università degli studi di Milano, Milan, Italy;1. Department of Cardiology, The Second Hospital of Shandong University, Jinan 250033, Shandong Province, China;2. Beijing Spirallink Medical Research Institute, Beijing 100054, China;3. Department of Respiratory Medicine, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China;1. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China;2. Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China;3. Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, PR China |
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| Abstract: | ObjectivesTuberculosis (TB) and nontuberculous mycobacteria (NTM) disease have similar symptoms, which makes them difficult to distinguish clinically and leads to the danger of NTM disease being neglected. The aim of this study was to assess the risk of developing mycobacterial disease among cancer patients.MethodsWe conducted a retrospective cohort study using a population-based database. The multivariable Cox proportional hazards model was adjusted to identify independent factors contributing to the development of mycobacterial disease in the cancer cohort.ResultsThe results showed that the increased risk of developing TB and NTM disease was 1.84-fold and 4.43-fold, respectively, in cancer patients compared with the general population. Advanced age (≥65years) and being male were risk factors for developing TB disease. There was a 4.09-fold significantly increased risk of TB disease within six months of a cancer diagnosis. Hematological cancer patients were most likely to develop mycobacterial disease. Younger hematological cancer patients (< 45years) had a higher risk of NTM disease development.ConclusionThere is an increasing risk of mycobacterial disease in cancer patients. We suggest that the possibility of mycobacterial disease in cancer patients should be assessed during the period of cancer therapy, particularly in those who have risk factors. |
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| Keywords: | Tuberculosis Nontuberculous mycobacterial disease Risk factor Cancer |
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