Pilot study of DNA methylation-derived neutrophil-to-lymphocyte ratio and survival in pediatric medulloblastoma |
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| Institution: | 1. Chang Gung University, Medicine, Taoyuan City, Taiwan;2. Department of Radiation Oncology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan;3. Division of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taiwan;4. Department of Otorhinolaryngology, Linkou Chang Gung Memorial Hospital, Taiwan;5. Department of Biomedical Sciences and Engineering, National Central University, Taiwan;6. Graduate Institute of Biomedical Engineering, Chang Gung University, Taiwan;7. Department of Otolaryngology-Head Neck Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taiwan |
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| Abstract: | IntroductionMethylation-derived neutrophil-to-lymphocyte ratio (mdNLR) has been identified as a potential prognostic biomarker of outcomes in various cancers. We evaluated the prognostic value of blood-derived mdNLR within a retrospective cohort of pediatric medulloblastoma patients.Materials and methodsDNA methylation was measured in archival peripheral blood samples collected on 56 pediatric medulloblastoma patients. Hazard ratios (HR) and 95% confidence intervals (CI) for the association between mdNLR and survival were evaluated using Cox proportional hazard models.ResultsCompared to patients who were alive at last follow-up (n = 43), the mean mdNLR value was slightly higher in deceased patients (n = 13) (12.3 vs. 5.2,P = 0.163). Elevated log-transformed mdNLR was suggestively associated with an increased likelihood of death in unadjusted models (HR=1.43, 95%CI: 0.92–2.22) and significantly associated with mortality in adjusted models (HR=1.61, 95%CI: 1.01–2.58).DiscussionFuture work is warranted to investigate the relationship between mdNLR outcomes in specific pediatric medulloblastoma molecular subgroups. |
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