Seven years prevalence and distribution of high and low risk HPV genotypes in women living in the metropolitan area of Naples |
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| Institution: | 1. Department of Experimental Medicine, Microbiology Section, University of Study of Campania “Luigi Vanvitelli”, Via De Crecchio, 7, 80138 Naples, Italy;2. Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie, 1, 80138 Naples, Italy;1. East Tallinn Central Hospital, Oncology Center, Ravi St 18, 10138 Tallinn, Estonia;2. National Institute for Health Development, Department of Epidemiology and Biostatistics, Hiiu St 42, 11619 Tallinn, Estonia;3. West Tallinn Central Hospital, Womens’ Clinic, Paldiski St 68, 10617 Tallinn, Estonia;4. Tartu University Hospital, Haematology and Oncology Clinic, L. Puusepa St 1A, 50406 Tartu, Estonia;1. Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;2. Division of Cancer Statistics Integration, Center for Cancer Control and Information Services, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;3. Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;1. Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, United States;2. International Agency for Research on Cancer, Lyon, France;3. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States;4. Institute of Population Health Sciences, National Health Research Institutes, Taiwan;5. Pôle Information Médicale Evaluation Recherche, Hospices Civils de Lyon, France;6. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan;7. Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;8. Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil;9. Department of Head and Neck, Heliopolis Hospital, São Paulo, Brazil;10. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy;11. Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, United States;12. Division of Head and Neck Surgical Oncology, Department of Otolaryngology/Head and Neck Surgery, Washington University School of Medicine, Saint Louis, MO, United States;13. Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy;14. Penn State College of Medicine, Hershey, PA, United States;15. University of Texas M. D. Anderson Cancer Center, Houston, TX, United States;p. Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Department of Urology, Medical School, University of Michigan, Ann Arbor, MI, United States;q. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital (CHUV), Lausanne, Switzerland;r. College of Public Health, University of Iowa, Iowa City, IA, United States;s. Brown University, Providence, RI, United States;t. Fred Hutchinson Cancer Research Center, Seattle, WA, United States;u. Washington State University College of Pharmacy, Spokane, WA, United States;v. University of Heidelberg, Heidelberg, Germany;w. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States;x. Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy;y. Department of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy;z. Department of Biomedical and Clinical Sciences, University of Milan, Italy;1. Division of Epidemiology, New York University School of Medicine, New York, United States;2. Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy;3. Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy;4. Department of Head and Neck Surgery, Institute of Clinical Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy;5. Istituto di Clinica Otorinolaringoiatrica, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy;6. Cancer Research Centre, Moscow, Russia;7. Escola Nacional de Suade Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil;8. ACCAMARGO Cancer Center, São Paulo, Brazil;9. Institute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina;10. Nofer Institute of Occupational Medicine, Lodz, Poland;11. Scientific Directorate, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy;12. National Institute of Health and Medical Research, Inserm U1018, Villejuif, France;13. Institute of Oncology and Radiobiology, Havana, Cuba;14. Universidade Federal de Pelotas, Pelotas, Brazil;15. Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil;P. National Institute of Public Health, Bucharest, Romania;Q. New York Eye and Ear Infirmary, New York, NY, United States;R. Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, United States;S. The M. Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Dept. of Cancer Epidemiology and Prevention, Warsaw, Poland;T. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany;U. Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany;V. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany;W. Regional Authority of Public Health in Banska Bystrica, Slovakia;X. National Institute of Environmental Health, Budapest, Hungary;Y. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States;1. Translational Oncology and Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King''s College London, Guy''s Hospital, 3rd Floor, Bermondsey Wing, London, SE1 9RT, UK;2. Departmetnt of Epidemiology, Institute of Environmental Medicine Karolinska Institutet, Stockholm, Sweden;3. St. John’s Institute of Dermatology School of Basic & Medical Biosciences, King''s College London, Guy''s Hospital, 9 Floor, Tower Wing, London, SE1 9RT, UK;1. Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA;2. Winship Research Informatics, Emory University, Atlanta, GA, USA;1. The Royal Brisbane and Women’s Hospital, Butterfield Street, Herston, Qld, 4029, Australia;2. Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, Qld, 4006, Australia;3. Cancer Alliance Queensland, Metro South Hospital and Health Service, 2 Burke St, Woolloongabba, Qld, 4102, Australia |
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| Abstract: | BackgroundThe objective of this work was to provide an update information on HPV age/genotype distribution by retrospectively analyzing a cohort of women living in the metropolitan area of Naples.MethodsFrom January 2011 to December 2017, cervical scrape specimens from 1265 women, with abnormal cytological indication, were tested for HPV DNA. The presence and the viral genotypes were assessed by the Linear Array HPV genotyping test for the detection of 37 anogenital HPV-DNA genotypes.ResultsThe overall prevalence of HPV infections was of 44.5% (95% CI 41.77–47.24). Among HR-HPV types, HPV-16 was the most common identified genotype, followed by HPV-31, -66, -59 and -51. As concern LR-HPV, HPV-53 resulted the most prevalent. Stratifying the study population by age, the total HPV infections showed a peak in younger women aged <23 years (58.5%), with a significative decrease by age (23–29 years, 54%; ≥ 30 years, 38.2%) (p < 0.001).ConclusionWe provided an HPV epidemiological analysis, highlighting the need to implement vaccination programmes and preventative screening strategies. |
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| Keywords: | Human papillomavirus Prevalence Epidemiology Genotypes distribution |
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