Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri |
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| Institution: | 1. Laboratoire de Chimie de Produits Naturels, UMR CNRS SPE 6134, University of Corsica, 20250 Corte, France;2. Institut de Chimie des Substances Naturelles ICSN-CNRS UPR 2301, Univ. Paris-Sud, 1 avenue de la terrasse, Labex CEBA, 91198 Gif-sur-Yvette, France;3. Laboratory for Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium;1. Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette cedex, France;2. Rega Institute for Medical Research (KU Leuven), Minderbroedersstraat 10, B-3000 Leuven, Belgium;3. Laboratoire de chimie des substances naturelles et des sciences des aliments (LCSNSA), Université de la Réunion, 15 Avenue René Cassin, 97715 Saint Denis Messag., Cedex 9-La Réunion, France |
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| Abstract: | The chemical study of the bark and the wood of Trigonostemon cherrieri, a rare endemic plant of New Caledonia, led to the isolation of a series of highly oxygenated daphnane diterpenoid orthoesters (DDO) bearing an uncommon chlorinated moiety: trigocherrins A–F and trigocherriolides A–D. Herein, we describe the isolation and structure elucidation of the DDO (trigocherrins B–F and trigocherriolides A–D). We also report the antiviral activity of trigocherrins A, B and F (1, 2 and 6) and trigocherriolides A, B and C (7–9) against various emerging pathogens: chikungunya virus (CHIKV), Sindbis virus (SINV), Semliki forest virus (SFV) and dengue virus (DENV). |
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