Ceramide,cerebroside and triterpenoid saponin from the bark of aerial roots of Ficus elastica (Moraceae) |
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Affiliation: | 1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;2. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China;1. School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4041, South Africa;2. Biodiversity Research, Assessment and Monitoring, South African National Biodiversity Institute, P.O. Box 52099, Berea Road, 4007, South Africa;3. Grup de Productes Naturals, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l''Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain;4. Natural Products Research Group, Department of Chemistry, University of Surrey, Guildford GU2 7XH, United Kingdom |
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Abstract: | Three compounds, ficusamide (1), ficusoside (2) and elasticoside (3), were isolated from the bark of aerial roots of Ficus elastica (Moraceae), together with nine known compounds, including four triterpenes, three steroids and two aliphatic linear alcohols. The chemical structures of the three compounds were established by extensive 1D and 2D NMR spectroscopy, mass spectrometry and by comparison with published data. The growth inhibitory effect of the crude extract and isolated compounds was evaluated against several microorganisms and fungi. The cytotoxicity against human cancer cell lines was also assessed. Ficusamide (1) displayed a moderate in vitro growth inhibitory activity against the human A549 lung cancer cell line and a strong activity against Staphylococcus saprophyticus, while elasticoside (3) showed a potent activity on Enterococcus faecalis. |
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