Verticillosides A–M: Polyoxygenated pregnane glycosides from Asclepias verticillata L. |
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| Institution: | 1. Departamento de Química, Universidade Federal de São Carlos, C.P. 676, CEP 13565-905 São Carlos, (SP), Brazil;2. Núcleo em Ecologia e Desenvolvimento Sócio Ambiental de Macaé, Universidade Federal do Rio de Janeiro - Campus Macaé, CEP 27910-970 Macaé, RJ, Brazil;3. Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal;4. Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, C.P. 676, CEP 13565-905 São Carlos, SP, Brazil;5. Departamento de Física e Informática, Instituto de Física de São Carlos, Universidade de São Paulo, Caixa Postal 369, CEP 13560-970 São Carlos, SP, Brazil;6. Laboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil;7. Universidade Federal de Ouro Preto, Campos Morro do Cruzeiro, CEP 35.400-000 Ouro Preto, MG, Brazil;1. Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, People''s Republic of China;2. The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, People''s Republic of China;1. Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China;2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China;3. Pharmacy Department of Tengzhou Central People Hospital, Tengzhou 277500, Shangdong Province, PR China |
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| Abstract: | As part of our ongoing effort to explore the chemical diversity of plants of the United States Midwest region, the isolation and identification of 13 pregnane glycosides named verticillosides A–M from Asclepias verticillata L. are reported. The structures of these compounds were elucidated by various spectroscopic techniques, including 1D and 2D NMR, IR, UV, and HRMS. The cytotoxicity of the isolates was evaluated against paired breast cell lines Hs578T (cancer) and Hs578Bst (normal), however, no significant growth inhibition was observed. |
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