Guanacastane-type diterpenoids from Coprinus radians |
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| Institution: | 1. Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;3. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;4. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;5. National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, MS 38677, USA;1. Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;2. State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;3. School of Life Science and Technology, Shanghai Tech University, Shanghai 201203, China;1. Laboratoire de Nutrition et Pharmacologie, UFR Biosciences, Université Felix Houphouët Boigny de Cocody-Abidjan, 22, BP 582 Abidjan 22, Cote d’Ivoire;2. LAPISEN, Groupe de recherche en Chimie des Eaux et des Substances Naturelles, Institut National Polytechnique Houphouët Boigny, BP 1313 Yamoussoukro, Cote d’Ivoire;3. CNRS, UPMC, LBBM, Observatoire Océanologique, 66650 Banyuls-sur-Mer, France;4. Laboratoire de Chimie Organique, UFR Sciences des Structures de la Matière et de Technologie, Université Felix Houphouet Boigny, 22, BP 582 Abidjan 22, Cote d’Ivoire;5. L3MA, UMR Ecologie des Forêts de Guyane, Université des Antilles et de Guyane, Campus de Troubiran, 97300 Cayenne, France;6. AM2N, Institut Charles Gerhardt, UMR 5253, ENSCM, 8 rue de l’Ecole Normale, 34296 Montpelier, France;7. CIRAD, Département Environnements et Sociétés, UMR Ecologie des Forêts de Guyane, BP 732, 97310 Kourou cedex, France;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China |
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| Abstract: | Thirteen diterpenoids, named radianspenes A–M (1–13), including three lactams radianspenes J (10), K (11) and L (12) and one dimer radianspene M (13), were isolated from fermentation products of the higher fungal strain Coprinus radians M65. All these compounds possessing guanacastane skeleton were evaluated for antitumor activity using MDA-MB-435 cell line. Radianspene C exhibited inhibitory activity with IC50 of 0.91 μM. |
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