Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp. of Zanthoxylum leprieurii |
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| Affiliation: | 1. Institute for Organic and Biomolecular Chemistry, Georg-August University, Tammannstrasse 2, D-37077 Göttingen, Germany;2. Division of Plant Pathology and Crop Protection, Georg-August University, Grisebachstrasse 6, D-37077 Göttingen, Germany;3. Institute for Microbiology, Technical University Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany;1. Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang 110016, Shenyang, PR China;3. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Shenyang, PR China;1. College of Food and Biology Engineering, Zhejiang Gongshang University, Hangzhou 310018, China;2. Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Hangzhou 310018, China;3. Ocean College, Zhejiang University, Hangzhou 310058, China;1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China;2. Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China;3. Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;4. School of Environmental Sciences, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada;5. University of Chinese Academy of Sciences, Beijing, 100049, China;1. School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China;2. School of Pharmaceutical Sciences, Engineering Research Center for Utilization of Tropical Polysaccharide Resources, Ministry of Education, Hainan University, Haikou, 570228, China |
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| Abstract: | Two polyketides, cryptosporiopsin A (1) and hydroxypropan-2′,3′-diol orsellinate (3), and a natural cyclic pentapeptide (4), together with two known compounds were isolated from the culture of Cryptosporiopsis sp., an endophytic fungus from leaves and branches of Zanthoxylum leprieurii (Rutaceae). The structures of these metabolites were elucidated on the basis of their spectroscopic and spectrometric data. Cryptosporiopsin A and the other metabolites exhibited motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola at 10–25 μg/mL. In addition, the isolated compounds displayed potent inhibitory activity against mycelial growth of two other peronosporomycete phytopathogens, Pythium ultimum, Aphanomyces cochlioides and a basidiomycetous fungus Rhizoctonia solani. Weak cytotoxic activity on brine shrimp larvae was observed. |
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