Slowness of blood flow and resultant thrombus formation in cerebral aneurysms |
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Authors: | Kenjiro Shimano Yosuke Aida Yuta Nakagawa |
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Institution: | (1) Department of Mechanical Systems Engineering, Faculty of Engineering, Tokyo City University, 1-28-1 Tamazutsumi, Setagaya, Tokyo 158-8557, Japan;(2) Graduate School, Tokyo City University, 1-28-1 Tamazutsumi, Setagaya, Tokyo 158-8557, Japan |
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Abstract: | It is not yet fully understood what causes cerebral aneurysms to rupture. Although no definitive conclusion has been reached,
it is considered that there are haemodynamic, biochemical and physiological factors contributing to rupture. Numerical techniques
seem promising for investigation of this multi-physical phenomenon. In fact, recent intensive numerical studies with computational
fluid dynamics have revealed detailed haemodynamic features of the flow in cerebral aneurysms such as velocity, pressure and
wall shear stress distributions. It is, therefore, expected that biochemical and physiological aspects of aneurysmal rupture
will also be actively investigated using numerical approaches. Considering this background, the authors have been working
on modelling of thrombus formation in cerebral aneurysms caused by stagnant blood flow, because many studies have suggested
that slow blood flow and resulting low wall shear stress are connected with rupture. Firstly, in this review paper, slowness
of the intra-aneurysmal flow is reviewed with an energy balance theory, and secondly, thrombus formation in cerebral bifurcation
aneurysms is discussed from the viewpoint of numerical modelling. A computational result obtained by application of the authors’
platelet aggregation–adhesion model is also provided. |
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