Protein kinase D: a family affair |
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| Authors: | Rykx An De Kimpe Line Mikhalap Svetlana Vantus Tibor Seufferlein Thomas Vandenheede Jackie R Van Lint Johan |
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| Institution: | Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium. |
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| Abstract: | The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCmu PKD2 and PKD3/PKCnu. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation. |
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| Keywords: | Protein kinase D Protein kinase Cμ Cell proliferation Apoptosis Signal transduction Golgi apparatus Stress signaling Tumor cell invasion |
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