No predictive value of GC phenotypes for HIV infection and progression to AIDS |
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| Authors: | Jan C Pronk Rune R Frants Bart Crusius Aldur W Eriksson Frank de Wolf Charles A B Boucher Margreet Bakker Jaap Goudsmit |
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| Institution: | (1) Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400 Tübingen, Germany;(2) DRK-Blutspendedienst, Soltauerstrasse 160, D-2720 Rotenburg/Wümme, Germany;(3) Abteilung Innere Medizin Il der Medizinischen Universitätsklinik, Otfried-Müller-Strasse 10, D-7400 Tübingen, Germany |
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| Abstract: | Summary Linkage data on human factor H (HF) and 22 other human genetic markers are presented. Close linkage at 0<0.10 can be ruled out for a series of marker systems (Rh, PGM1, ACP1, Jk, Tf, Gc, MNSs, ME2, HLA, GLO1, ORM, Gt, PI, Hp, GPT). Strong evidence for linkage was obtained for peptidase A (PEPA) with lods >3.0 at  =0.10 in males and at =0.20 for the sexes combined. From this result the HF locus can be provisionally assigned tochromosome 18. |
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